It is all dependent on what symptoms you are currently working on and how your body normally feels. Some take for a three month course to do a gentle liver cleanse. Some for the rest of their lives who are battling liver disease.
The experience of taking Milk Thistle is different for most people especially in the beginning detox phase. But after a few weeks the general response we get is the same; a feeling of being more clear, less toxic, and more in balance. If you want to read about detox, we posted an article at:
basics of detox. Hope this helps. Let us know if we can answer any more questions.