Platelet-activation molecule CD62P and CD63 on platelets in psoriatic patients

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Relationship between syndrome differentiation-typing and expression of platelet-activation molecule CD62P and CD63 on platelets in psoriatic patients

[Article in Chinese]

Li GY, Liu HC, Yin GP.

Department of Dermatology, Jinan Military General Hospital.

OBJECTIVE: To understand the relationship between Syndrome Differentiation- Typing and platelet activation in psoriatic patients. METHODS: Expression of platelet-activation molecules CD62P (alpha-granule membrane glycoprotein) and CD63 (lysosomal integral membrane protein) on platelets from 36 psoriatic patients with Syndrome Differentiation-Typing in TCM and 31 health subjects were investigated by using flow cytometry and specific monoclonal antibodies against activated platelet. RESULTS: (1) Increased expression of CD62P and CD63 on platelets from psoriatic patients was observed (P < 0.001); (2) The expression of CD62P and CD63 was in following order: The group of Blood Stasis > Blood Dryness > Blood Heat; (3) Compared with the group of Blood Heat, increased expression of CD62P and CD63 was observed in the group of Blood Dryness (P < 0.001); (4) Compared with the group of Blood Dryness, increased expression of CD62P and CD63 was observed in the group of Blood Stasis (P < 0.001). CONCLUSION: The platelet activation might play an important role in higher blood viscosity, endothelial cell injury, abnormal microcirculation, which was correlated with Blood Stasis, found in psoriasis.

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Jul;17(7):417-8.
PMID: 10322863 [PubMed - indexed for MEDLINE]